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For example, you can look at your mom’s laptop or brother’s gaming PC through a single interface. By taking a mathematical approach to malware identification utilising. If you do want access to all the data and threat details, there is a web dashboard where you can manage settings, including receiving alerts if an attack is blocked, and garner a top-down view of all devices that are covered by the software. Cylance leverages AI to detect and prevent malware from executing in real time. CYLANCE ANTIVIRUS ARTIFICIAL INTELLIGENCE SOFTWAREThis should also mean that it won’t hog your system’s resources trying to battle a breach.Ĭylance said that its new antivirus software runs constantly in the background without any “noticeable degradation of device performance,” while it updates automatically with no pop-ups, scan requests, reboots, or any other kind of shenanigans. 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Cylance Protect Cylance Protect is an advanced threat protection program that utilizes machine learning and artificial intelligence to categorize files and. In 2014 we added intelligent compression for JPEG images and in 2016 we added support for animated PNG. We created TinyPNG in our quest to make our own websites faster and more fun to use with the best compression. Why did you create TinyPNG?Įxcellent question! We frequently use PNG images, but were frustrated with the load times. It allows you to scale, preview and save compressed PNG and JPEG images straight from Photoshop. Image convert install#You can also install the TinyPNG Photoshop plugin. We’ll convert them to tiny indexed PNG files. You can use Save for Web to export your images as 24-bit transparent PNG files and upload them to TinyPNG. With other versions it is impossible and Photoshop CS5 cannot even display them properly. What about Photoshop?Įxcellent question! 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Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.Copenhagen Hepatitis C Program (CO-HEP), Department of Infectious Diseases, Hvidovre Hospital, and Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA. CIRI, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, École Normale Supérieure de Lyon, Univ Lyon, F-69007, Lyon, France.Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA., Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.(ANL), Argonne, IL (United States) Sponsoring Org.: USDOE Office of Science (SC), Basic Energy Sciences (BES) OSTI Identifier: 1643153 Alternate Identifier(s): OSTI ID: 1816246 Grant/Contract Number: AC02-06CH11357 Resource Type: Published Article Journal Name: Science Advances Additional Journal Information: Journal Name: Science Advances Journal Volume: 6 Journal Issue: 30 Journal ID: ISSN 2375-2548 Publisher: American Association for the Advancement of Science (AAAS) Country of Publication: United States Language: English Subject: 59 BASIC BIOLOGICAL =, Publication Date: Fri Jul 24 00:00: Research Org.: Argonne National Lab. Hepatitis C virus (HCV) envelope glycoproteins E1 and E2 are responsible for cell entry, with E2 being the major target of neutralizing antibodies (NAbs). Here, we present a comprehensive strategy for B cell–based HCV vaccine development through E2 optimization and nanoparticle display. We redesigned variable region 2 in a truncated form (tVR2) on E2 cores derived from genotypes 1a and 6a, resulting in improved stability and antigenicity. Crystal structures of three optimized E2 cores with human cross-genotype NAbs (AR3s) revealed how the modified tVR2 stabilizes E2 without altering key neutralizing epitopes. We then displayed these E2 cores on 24- and more » 60-meric nanoparticles and achieved substantial yield and purity, as well as enhanced antigenicity. In mice, these nanoparticles elicited more effective NAb responses than soluble E2 cores. Next-generation sequencing (NGS) defined distinct B cell patterns associated with nanoparticle-induced antibody responses, which target the conserved neutralizing epitopes on E2 and cross-neutralize HCV genotypes. « lessĮlicitation of broadly neutralizing antibodies (bnAbs) is a leading strategy in rational vaccine design against antigenically diverse pathogens. Here, we studied a panel of monoclonal antibodies (mAbs) from mice immunized with the hepatitis C virus (HCV) envelope glycoproteins E1E2. Six of the mAbs recognize the conserved E2 antigenic site 412–423 (AS412) and cross-neutralize diverse HCV genotypes. Immunogenetic and structural analysis revealed that the antibodies originated from two different germline (GL) precursors and bind AS412 in a β-hairpin conformation. Intriguingly, the anti-HCV activity of one antibody lineage is associated with maturation of the light chain (LC), whereas the other lineage is more » dependent on heavy-chain (HC) maturation. Crystal structures of GL precursors of the LC-dependent lineage in complex with AS412 offer critical insights into the maturation process of bnAbs to HCV, thus providing a scientific foundation for utilizing the mouse model to study AS412-targeting vaccine candidates. Hepatitis C virus (HCV) is a positive-strand RNA virus within the Flaviviridae family. The viral “spike” of HCV is formed by two envelope glycoproteins, E1 and E2, which together mediate viral entry by engaging host receptors and undergoing conformational changes to facilitate membrane fusion. Meanwhile Westermark and collaborators have elegantly characterized the constituents of TTR amyloid fibrils extracted from cardiac amyloid deposits and adipose tissue, identifying two clearly distinct categories ( 8, 9). The protease responsible has not yet been identified, but the highly specific cleavage suggests that it could be a trypsin-like serine protease. In addition to full-length TTR monomers, Lundgren’s group identified the residue 49-127 fragment, generated by proteolytic cleavage of the peptide bond Lys48–Thr49 ( 7), as the main fragment present in ex vivo TTR amyloid fibrils. However, binding of RBP, but not thyroxine, inhibited subsequent fibrillogenesis. Binding of the natural ligands thyroxine or retinol-binding protein (RBP) by Ser52Pro variant TTR stabilizes the native tetrameric assembly, but neither protected the variant from proteolysis. We thus provide a structural basis for the recently hypothesized, crucial pathogenic role of proteolytic cleavage in TTR amyloid fibrillogenesis. The remarkable susceptibility to such cleavage is likely caused by localized destabilization of the β-turn linking strands C and D caused by loss of the wild-type hydrogen-bonding network between the side chains of residues Ser52, Glu54, Ser50, and a water molecule, as revealed by the high-resolution crystallographic structure of Ser52Pro TTR. In physiological conditions and under agitation the residue 49-127 proteolytic fragment rapidly and completely self-aggregates into typical amyloid fibrils. This specific truncation of Ser52Pro TTR was generated readily in vitro by limited proteolysis. Together with a minor quantity of full-length wild-type and variant TTR, the main component of the ex vivo fibrils was the residue 49-127 fragment of the TTR variant, the portion of the TTR sequence that previously has been reported to be the principal constituent of type A, cardiac amyloid fibrils formed from wild-type TTR and other TTR variants. The Ser52Pro variant of transthyretin (TTR) produces aggressive, highly penetrant, autosomal-dominant systemic amyloidosis in persons heterozygous for the causative mutation.
This cookie is set by GDPR Cookie Consent plugin. The cookie is set by GDPR cookie consent to record the user consent for the cookies in the category "Functional". The cookie is used to store the user consent for the cookies in the category "Analytics". These cookies ensure basic functionalities and security features of the website, anonymously. Necessary cookies are absolutely essential for the website to function properly. #SCRIPT STUDIO VERSUS FINAL DRAFT SOFTWARE#This software is primely for screenwriters who are working with a team. #SCRIPT STUDIO VERSUS FINAL DRAFT FREE#There is a free version that allows you to test it out on up to three screenplays, then various monthly plans. With Writer Duet, you can edit and video chat on both desktop and mobile. Most script software collaboration features don’t support mobile phones. For example, to use real-time collaboration in Final Draft both writers need to own the same software. #SCRIPT STUDIO VERSUS FINAL DRAFT PROFESSIONAL#Unlike other professional platforms, each writer doesn’t need to own the same scriptwriting software. You own the screenplay rights and everything is kept secure within the online system. Writer Duet is a cloud-based platform, and your files are saved locally via Google Drive, Dropbox, or iCloud. You can use Writer Duet with any file format and edit with another writer anywhere in the world. This software is all about collaboration, with real-time editing functions. $7.99 monthly subscription (Mac and Windows) Best For screenwriters who are character-focused and like analytics. Highland is a more affordable platform but is unfortunately only available on Mac. #SCRIPT STUDIO VERSUS FINAL DRAFT PDF#The free trial allows you to write unlimited scripts but saves PDF files with a watermark. Highland is also not just for scripts but can be used for writing articles, novels, blog posts, and pretty much anything. Which allows you to give yourself word or page count goals each day. A recent unique feature is gender analysis, which allows you to see how much screentime is split between male and female characters.Īnother feature is it’s goals and stats tracker. You can easily list and keep track of your characters. Unlike other software available, Highland comes with advanced character organization. It allows you to easily focus on the writing and automatically formats for you. In particular screenwriter and blogger John August (Big Fish, Aladdin). Unlike all other programs, it was developed by screenwriters. Highland is a more modern and stylish script writing software. So, even if you are editing with software, saving your screenplays as Fountain plain text makes sense. However, many professional programs still don’t allow as much versatility as Fountain. Since the creation of Fountain more software has been made that has these additional features. One other advantage of Fountain is that it allows you to edit your script anywhere so from a mobile phone or iPad for instance. Scriptwriting software formats for you, but it can be difficult to transfer and collaborate with different programs. Many screenwriters learn Fountain formatting and save their screenplays in plain text. So start your page with a scene header, place character names in capital letters and follow a name with dialogue. The syntax rules for writing in Fountain are simple, make your text look like a screenplay. By formatting, in Fountain, your script can be uploaded in the future on any screenplay software. So, if you are using a plain text document to write your screenplay use fountain formatting. This allows you to write in script format on any device and transfer it to any additional software.įountain is not an app but a set of rules for writing a screenplay in plain text. The first most popular screenplay writing format is Fountain, a simple markup syntax for writing and editing screenplays. This will require TappedOut.js included in your blog. In TappedOut's comments/forums In TappedOut's comments/forums with pie-chart On your blog You can now import it in the MTG Arena client. MTG Arena Copy to clipboard 1 Argentum Armor (AFC) 198Ĭopied to clipboard. See my other Geth deck listings for differences and ideas. Look for gems like Sins of the past where you can still pay Strive and Entwine costs and Scaretiller to get back your Cabal Stronghold - your poor main's Cabal Coffers - or ramp out excess swamps in hand with it and tap shenanigans with Clock of Omens and Sol Ring or Worn Powerstoneįor those who have the cards or are not on this strict a budget, start replacing cards with similar effects, but more efficient, more $costly$ cards e.g. You have plenty of recursion to get back all of your cards. The plan is the same: ramp, board wipe, control the board as you draw and grow your manabase, and then turn the corner when you play Geth and start using your opponent's graveyards against them. This deck is a solid 6 to 6.5 as it synergizes well with itself but plays essentially more expensive (mana-wise) cards instead of more efficient cards that are more expensive (dollar-wise). You can build this whole deck for less than $100, easily. This went from a 'cheap' version to a TRUE budget version. Geth, Lord of the Vault (Commander) 252 decks (0.016) Rank 885. Bojuka Bog is going against the grain but can be fine too. Geth, Lord of the Vault As Commander As Card Average Deck Decks. I suggest Crypt Incursion, Withered Wretch, and Shred Memory. You can easily put in spot removal GY hate if you so desire. The only thing you need to watch out for is GY recursion decks as your mill can fuel them. It's actually about 75% as effective of my expensive Geth build. You can easily soup this deck up, but its really fun and fair for a reasonable cost where you play a commander no one plays (and more should). Now by having ramped into big mana territory after the sweeper, you use your opponent's creatures and artifacts against them with Geth. I've taken most of the complexity and flourish out - this is very utilitrian, but extremely flexible with Geth being able to use off-color creatures that you sweep away. The only cards in here that are more than $10 TCG-Mid are mana-producing cards - that is how important they are. A budget and very fair version of my favorite EDH deck - Geth, Lord of the Vault. Depending on the length and complexity, the generator will tell you whether your chosen password is bad, weak or strong. You can now move the slider along the bar to alter the length. You then can include or exclude letters, mixed case characters, punctuation or numbers. First, set the length anywhere from four to 64 characters. The Norton Password Generator helps you pick the right password by indicating whether it’s weak or strong. Click the Refresh button to create a password and then click the Copy button to paste it somewhere else. Choosing either of the other two options allows you to also include or exclude numbers and symbols. Choosing the first option lets you include or exclude uppercase and lowercase characters. 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Many security experts recommend using passphrases as they’re often easier to remember and can be just as secure as a complex password. The 1 1Password Strong Password Generator will generate passphrases and PINs as well as passwords. To help you remember your new password, the site suggests words that start with each letter in the password. If you like it, click the Copy button so you can paste it elsewhere. When you’re ready, click the button for Generate Password. By default, the password is generated on your device rather than transmitted over the internet. You can exclude similar characters in the same password as well as ambiguous characters. Next, you decide whether to include symbols, numbers, lowercase characters and uppercase characters. But remember it’s not just the length of your password that determines its strength but its complexity. Anything less than 16 characters is considered weak, between 16 and 128 characters is considered strong and anything 256 characters or more is considered unbelievable. Secure Password GeneratorĪt the Secure Password Generator website, you first specify the length of the password you need. Here are six password generators that can help you create secure passwords for any type of account. SEE: Password breach: Why pop culture and passwords don’t mix (free PDF) (TechRepublic)Īt most password generator sites, you’re able to control the type of password created by specifying a length and choosing whether to incorporate numbers, symbols and special characters. These sites cook up random and strong passwords that you can apply to your own accounts. But if you don’t have a password manager, another option is to use an online password generator. A password manager is your best bet for doing this. One of the best ways to protect your online and internal accounts is to devise unique and complex passwords. #STRONG PASSWORD GENERATOR MULTIPLE HOW TO#How to secure your email via encryption, password management and more (TechRepublic Premium) In security, there is no average behavior #STRONG PASSWORD GENERATOR MULTIPLE ANDROID#Image: Getty Images/iStockphoto Must-read security coverageĨ5% of Android users are concerned about privacyĪlmost 2,000 data breaches reported for the first half of 2022 How to generate secure passwords for your accountsĪ password generator can help when you need a strong and complex password to protect an account. Stanley is reverential about adhering to the employee handbook, while Jevon is clearly too smart to be slinging sandwich patties for minimum wage and has no intention of busting his ass in a thankless court-ordered job. The odd-couple interplay between straight-arrow Stanley and politically outspoken Jevon, with his eye-rolling attitude, fuels much of the shrewdly observed early humor. Jevon, however, has barely looked at the boy since getting out of county lockup. Jevon’s girlfriend Sidney (Birgundi Baker) has also seen her plans to study law stalled, sacrificing her college track scholarship to stay home and take care of their young son. Having quit his job to move to Florida and pull his ailing mother out of a retirement home, Stanley is entrusted with the training of his replacement Jevon (Shane Paul McGhie), a once-promising young African American writer, on probation for defacement of a public monument. He even seems impervious to the thinly veiled mockery of football jocks who pick up sandwiches from his drive-through window. Stanley is one of those characters in movies about the American underclass who comes under the reductive general header of “sad-sack loser,” yet he’s distinguished by a pride in his work and refusal to bemoan his dead-end life that gives him a touching resilience.
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